UpdateMyHealth.com is a website for people who want to know about sulforaphane, a compound obtained from cruciferous vegetables such as broccoli sprouts, Brussels sprouts, and cabbages.

I encountered sulforaphane while researching ways to lower systemic inflammation and was impressed by the sheer volume of scientific scrutiny this compound has been subjected to.

Sulforaphane is a molecule within the isothiocyanate group of organosulfur compounds. It is produced when the enzyme myrosinase transforms glucoraphanin into sulforaphane upon damage to the plant (such as from chewing or blending, which allows the two compounds to mix and react).

I discovered that sulforaphane is an Nrf2 “activator”. Nrf2 is a powerful protein that is latent within every cell in the body, unable to operate until it is released by an Nrf2 activator. Once activated Nrf2 regulates a wide variety (over 200) antioxidant, detoxification, and cell survival genes.

I began to understand how sulforaphane epigenetically works through the Nrf2 pathway to:

  • Drive inflammation reduction.
  • Deactivate inflammation genes.
  • Activate antioxidant genes.
  • Deactivate carcinogens, convert them to water soluble conjugates and excrete them.


Note: I have no affiliation with any product or company mentioned on this website.

Disclaimer: The information I provide here is not intended to replace recommendations or advice from physicians or other healthcare providers. Rather, it is intended to help you make informed decisions about your health and to cooperate with your healthcare provider. If you suspect you have a medical problem, I strongly urge you to seek medical attention from a competent healthcare provider.